In stark contrast, In comparison, On the other hand, While, In sharp contrast
Structure
Noun＋にひきかえ
［な］Adjective＋な・である＋の＋にひきかえ
［い］Adjective＋の＋にひきかえ
Verb＋の＋にひきかえ
Phrase (A)。それにひきかえ、Noun は＋Phrase (B)
(A) にひきかえ (B) is used to contrast two things/people/animals and so on subjectively. The speaker considers (A) and (B) to be complete opposites and evaluates one of them positively (usually A) and the other negatively (usually B).
The それにひきかえ pattern is the most common.
にひきかえ is used with factual clauses, so it is generally not used with expressions of conjecture like かもしれない and the like.