cannot
there is no way one can
nothing one can do
cannot possibly not by any means
cannot do no matter how hard one tries
nothing will come out
it is meaningless to
Structure
どうにも （こうにも ） + (Negative)Verb［できる］
どうにも （こうにも ） + Verb［ます］+ ようがない
どうにも できない
どうにも （こうにも ）ならない
どうにもA is used to emphasize feelings of dissatisfaction, regret when no matter what one says or does, A is impossible and nothing can be done about it. The phrase is used in two common set expressions: 「どうにもならない」and 「どうにもできない」. どうにもこうにも is sometimes used for more emphasis.